Lifetime Achievement Award
- 2017 Morris (Mickey) Milner
- 2016 Murray McLaughlin
- 2015 John Oliver
- 2014 Mark Lievonen
- 2013 Mark Poznansky
- 2012 Joseph Rotman
- 2011 Calvin Stiller
- 2010 John Dirks
- 2009 Ed Rygiel
- 2008 Alan Bernstein
- 2007 Bill Cochrane
- 2006 Lou Siminovitch
- 2005 Henry Friesen
- 2004 John Evans
- 2003 Graham Strachan
Company of the Year
- 2017 Synaptive Medical
- 2016 Profound Medical Inc.
- 2015 Xagenic Inc.
- 2014 DVS Sciences
- 2013 EcoSynthetix
- 2012 ArcticDX Inc
- 2011 YM Bioscience
- 2010 Axela
LSO Volunteer Award
- 2017 Alison Symington
- 2016 Jason Locklin
- 2015 Christine Beyaert
- 2014 Andrew Yoshioka
- 2013 Magda Choruzy
- 2012 John Kelly
- 2011 Bonnie Keuhl
- 2010 Gregg Szabo
- 2009 Adi Treasurywala
- 2008 John Goudey
- 2007 Matt Buist
- 2006 Dale Patterson
- 2005 Grant Tipler
- 2004 Jeff Graham
- 2003 Lorne Meikle
LSO Leadership Award
- 2017 Russell Williams
- 2016 David Allan
- 2014 Jason Locklin
- 2014 Lorne Meikle
- 2014 Grant Tipler
- 2014 Jack Wearing
Community Service Award
- 2017 Raphael (Rafi) Hofstein
- 2016 Bonnie Schmidt
- 2016 Allison Barr
- 2015 Luis Barreto
- 2015 Deb Stark
- 2014 Ronald Pearman
- 2013 Ulrich Krull
- 2013 Maurice Bitran
- 2012 Peter Singer
- 2012 George Ross
- 2011 Gord Surgeoner
- 2011 Len Crispino
- 2010 Murray McLaughlin
- 2010 Marc LePage
- 2009 Mayor Hazel McCallion
- 2009 Bruce Archibald
- 2008 Susan Smith – RBC
- 2008 David Lindsay – Province of Ontario
- 2007 John Cook – MaRS
- 2007 Tim McTiernan – Province of Ontario
- 2006 Ken Knox – Innovation Institute of Ontario
- 2005 Janet Lambert – BioteCanada
- 2004 Michael Vaughan – ROB TV
- 2003 Mark Lievonen
- 2002 Cal Stiller – Canadian Medical Discoveries Fund
- 2001 John Goudey – Ernst & Young
- 2000 Hon. Jim Wilson – Member of Provincial Parliament
- 1999 William Mak – Seneca College
- 1998 no awards
- 1997 Lap Chee Tsui – The Hospital for Sick Children
- 1996 Jeffrey Graham – Borden Ladner Gervais LLP
- 1995 Alan Bernstein – Samuel Lunenfeld Research Institute
- 1994 Michael Walcroft – Connaught Laboratories
- 1993 Graham Strachan – Allelix
- 1992 Jerry Ormiston – Allelix
- 1991 Dr. Lou Siminovich – Samuel Lunenfeld Research Institute